Imaging Innovation Frontier
In Midtown Manhattan
MRI, PET-MR, and CT development
• over 100 specialists
• matrixed, interdisciplinary teams
• rapid clinical translation
• worldwide research collaborations
• state-of-the-art equipment
• specialized graduate and doctoral training
speakers, presenters, and attendees
for making i2i Workshop a success!
This October, nearly 300 scientists, clinicians, engineers, and programmers from tech and academia met at CAI2R to explore latest trends and define what's next for biomedical imaging.
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Meet Our Personnel
• 70+ basic research staff, 30+ clinical collaborators
• Onsite industry partners & frequent collaborative visits
• Ten founding partner clinical departments
• Multidisciplinary research programs
• Bi-directional teaching & learning by clinicians & scientists
• Integrated Graduate Program on Biomedical Imaging
• Hands-on educational offerings in RF engineeringSee the Course Program
›› Bringing People Together to Create New Ways of Seeing ‹‹
Center for Advanced Imaging Innovation and Research
News & Highlights
"Seeing the Invisible"
On Monday, March 30th, Dmitry Novikov will give a talk on breaking through the Magnetic Resonance Imaging (MRI) resolution limits to the tissue microstructure below.
"Seeing the Invisible," a lecture by Dmitry Novikov
On Monday, March 30th, Dmitry Novikov, Assistant Professor at NYU Center for Biomedical Imaging, will give a talk on breaking through the Magnetic Resonance Imaging (MRI) resolution limits to the tissue microstructure below.
MRI allows clinicians to see structures as small as one millimeter, roughly at the resolution of unaided human sight. At this scale, we can distinguish tissues—but not individual cells they’re composed of. “It’s a hard limit,” said Dr. Novikov in an interview, noting that to see such minutiae through MRI in vivo radiologists would have to scan patients with prohibitively strong magnets for extraordinarily long periods. In other words, “you cannot buy your way out of the limit”—but you may be able to think your way out.
In his lecture, titled Seeing the invisible: Tissue structure at the cellular lever with MRI, Dr. Novikov will talk about using MRI to glimpse microstructures one thousand times smaller than one millimeter. “That’s where physiology happens, that’s where pathology develops,” he noted. This relatively new and still emerging way of seeing depends on taking MRI measurements with conventional millimeter-scale resolution, and developing theoretical models to interpret the resulting data in terms of changes occurring at the scale of microns.
Dr. Novikov’s lecture is a part of the Translational Research In Progress (TRIP) Seminar series hosted by the Clinical and Translational Science Institute, an interdisciplinary partnership among New York University, the NYU Langone Medical Center, and the New York City Health and Hospitals Corporation.
Details: Monday, March 30th, 1:00pm, Smilow Research Center (map), 1st Floor Multipurpose Room.
In a paper published recently in NMR in Biomedicine, Florian Knoll describes a new way to reconstruct parametric maps from scan data in diffusion MRI.Read more
SPIE 2015 Lecture
During this year’s SPIE Medical Imaging conference, CAI²R's Dan Sodickson gave a plenary lecture on "The Rapid Imaging Renaissance", which is now available online.Read more
Researchers at NYU’s Center for Advanced Imaging Innovation Research have developed a new way to measure changes in microstructure of muscle fiber.Read more
Diffusion Imaging of Cartilage Makes JMRI Cover
The journal JMRI highlights Jose Raya's work on diffusion tensor imaging assessments of articular cartilage.
Diffusion Imaging to Assess Cartilage Makes JMRI Cover
In the June issue of the Journal of Magnetic Resonance Imaging, Dr. Raya, who develops methods for early detection of osteoarthritis, describes diffusion tensor imaging (DTI) techniques for assessment of cartilage composition and structure. In particular, he employs two DTI measures—mean diffusivity and fractional anisotropy—to evaluate two fundamental elements of cartilage tissue—proteoglycan and collagen.
The images on the cover of JMRI show longitudinal changes in DTI measurements of the knee in two patients diagnosed with osteoarthritis. The data indicate that proteoglycan content may decrease even as the structure of collagen fibers remains relatively stable. The results also demonstrate that diffusion parameters can characterize physiological changes occurring over time. Read about this and related techniques in Dr. Raya’s paper, Techniques and application of in vivo diffusion imaging of articular cartilage.
MRI for Next Generation Smartphones
NYU researchers advocate new wireless safety standards, with MRI playing key role.Read more
NYU at ISMRM 2015
CAI2R scientists presented latest research and shared expertise at the 23rd annual meeting of the International Society for Magnetic Resonance in Medicine.Read more
Fernando Boada Named Distinguished Investigator
The Academy of Radiology Research, has named CAI2R director Fernando Boada a Distinguished Investigator.
An advocacy based in Washington, D.C., the Academy of Radiology Research champions recognition of the role of imaging research in medical practice, and advocates dedicated funding for imaging technologies that profoundly influence healthcare.
This year the academy has honored Dr. Fernando Boada alongside 36 researchers “for their accomplishments in imaging research” and to “especially encourage those who have achieved scientific excellence while still being involved in clinical care,” according to a congratulatory letter from the Distinguished Investigator Council.
As principal investigator, Dr. Boada leads a technology research and development (TR&D) project to develop convergent MR-PET acquisition and reconstruction methods that go beyond the conventional superposition of MR and PET data.
Coming this October: i2i workshop!
Save the date for the 2-day Innovation to Implementation in Imaging (i2i) Workshop in NYC!Read more
MRM highlights XD-GRASP, developed at CAI2R
Magnetic Resonance in Medicine Journal highlights XD-GRASP in a Q&A with Dr. Li Feng and Dr. Ricardo Otazo.
In a Q&A with MRM, Li Feng, PhD, and Ricardo Otazo, PhD, discuss XD-GRASP, an imaging method that combines golden-angle radial sampling with compressed sensing to track and freeze periodic motion.
"XD" in "XD-GRASP" stands for "extra dimensional," because the technique captures more than the four dimensions we experience directly (length, width, height, and time). The method enables reconstruction of additional dimensions associated with periodic motion, such as the cycle of heartbeat or breathing.
With XD-GRASP, organs affected by periodic motion can be "frozen" after reconstruction. The heart, for instance, which not only beats but also rises and falls, pushed up and pulled down by the diaphragm, can be shown and examined as if beating in a still environment, unaffected by breathing.
Watch Dr. Feng's presentation summary of XD-GRASP:
P41 Directors Meet
CAI2R Directors attend the 2016 P41 Principal Directors' Meeting in Rockville, MD.
CAI2R Director, Fernando Boada, PhD, and CAI2R Principal Investigator Dan Sodickson, MD, PhD, convene with more than 130 scientists from over 20 other National Biomedical Technology Resource Centers and from the National Institutes of Health.
Dr. Sodickson will deliver a talk, The Changing Face of Biomedical Imaging: From Still Photography to Streaming Information, in which he will summarize the current state of imaging science, describe mounting demands for imaging to deliver greater measurable value in healthcare, and argue that the answer to those demands lies in development of rapid continuous comprehensive imaging technology. CAI2R is working toward making that vision a reality every day.
CAI2R goes to Singapore to exchange ideas with other members of the International Society of Magnetic Resonance in Medicine at the 24th annual ISMRM meeting.
CAI2R and NYU School of Medicine team comprising scientists, clinicians, technologists, and graduate students will deliver over 100 research events, including educational talks, focused discussions, oral presentations, as well as electronic and traditional posters.
The research team will present work in areas as diverse as:
- preclinical imaging
- cutting-edge diffusion methods
- RF engineering
- new frontiers in image reconstruction
- breast cancer
and many, many more. For details, see ISMRM proceedings.
MRI Points to Possible Links Between Fatty Acids and Cancer
Clinically feasible, rapid, in-vivo method details fatty acid composition in the breast.
In a study published in Radiology, CAI2R researchers investigate possible association of fatty acid fractions of adipose tissue with breast cancer.
Using a novel method, multiple gradient-echo MR spectroscopy imaging, the investigators measured fractions of monounsaturated, polyunsaturated, and saturated fatty acid in breast adipose tissue of pre- and postmenopausal women with and without breast cancer. In the paper, authors write, “Our study demonstrated that, for postmenopausal women, low monounsaturated and high saturated fatty acids may be associated with invasive ductal carcinoma, which potentially makes them useful indicators of the presence of breast cancer.”
The method is non-invasive and can be “easily used in the clinic during a routine diagnostic protocol,” according to the authors.
Read the associated RSNA press release.
Read the associated NYU Langone press release.
Read the study: Evaluation of Breast Lipid Composition in Patients with Benign Tissue and Cancer by Using Multiple Gradient-Echo MR Imaging.
MRM Highlights CAI2R Scientists' Work on Gibbs Ringing
CAI2R scientists chat with MRM about use of regularization functions to mitigate Gibbs ringing artifacts in diffusion MRI.Read more
NYU Radiology and CAI2R in Recent News
NYU Langone and CAI2R are in the news about operational and technological innovation in radiology.
Although at many medical centers increased specialization has distanced radiologists from other clinicians, at NYU Langone radiologists participate in the clinical mix through virtual rounds and contribute nuanced analyses to collaborative patient care. Read The Wall Street Journal profile of integrative radiology operations at NYU Langone.
Meanwhile, at NYU Langone's Center for Biomedical Imaging—home of CAI2R—imaging scientists are using insights from MRI applications of compressed sensing to develop ultra-low-dose CT. Read Radiology Business Q&A with CAI2R researchers about a new approach to CT dose reduction.
Plug-and-Play Fingerprinting appears in Nature
CAI2R scientists publish a paradigm-shifting method called Plug-and-Play Fingerprinting in Nature Communications.
In research published today by Nature Communications, Drs. Cloos and Sodickson of CAI2R describe a multiparametric quantitative imaging method unaffected by RF field variations. The advance overturns decades-long assumptions about the necessity of pursuing uniform RF fields and opens doors to quantitative MRI results that accurately compare across scanners and patient populations.
The method, called Plug-and-Play MR Fingerprinting (PnP-MRF) has been validated in simulations, phantom studies, and in vivo. Read related press release by NYU Langone Medical Center.
CAI2R Holds Innaugural i2i Workshop
About 300 scientists and tech experts visit CAI2R to envision the future of biomedical imaging.Read more
American Heart Association Names Leon Axel Distinguished Scientist
Leon Axel, MD, PhD, awarded by AHA for imaging research that "importantly advanced our understanding of cardiovascular diseases and stroke."Read more
Biomedicine and Engineering Connect
CAI2R Radiologists participated in “Connecting the Dots: Engineering Meets Biomedical Research"
Organized by the Office of Science and Research at NYU Langone Medical Center on December 8, "Connecting the Dots" highlighted collaboration between NYU School of Medicine and NYU Tandon School of Engineering, and encouraged exploration of new joint research projects.
CAI2R scientists, Yvonne W. Lui, MD, and Riccardo Lattanzi, PhD, presented ongoing cross-disciplinary research conducted with colleagues from NYU Tandon. Dr. Lui (pictured) discussed the role of computational methods and advanced MRI in investigations of traumatic brain injury—a collaboration with Yao Wang, PhD, of NYU Tandon. Dr. Lattanzi, alongside colleagues from the schools of medicine and engineering, discussed collaborative investigations of medical image analysis at Tandon’s VIDA Center.
After presentations, scientists held a networking session to explore pressing challenges in biomedicine and bioengineering, and to envision new joint investigations. Dafna Bar-Sagi, PhD, Vice Dean for Science and Chief Scientific Officer at NYU Langone, challenged the teams to focus on the most timely questions, the disciplines that can best address them, and areas of particular opportunity.
XD-GRASP Article Makes Waves among MRM ReadersRead more
Diffusion Time Matters in Prostate Cancer
In new Investigative Radiology paper, CAI2R scientists show that diffusion time reveals information that may help detect and grade prostate cancer. Urology Today reports on findings.Read more
Diffusion in Muscle: "Outstanding"
Editorial in special issue of NMR in Biomedicine calls CAI2R investigators' work an "outstanding example of ongoing methodological research in diffusion MR outside the brain."Read more