We are making available code for Monte Carlo simulations of two-dimensional water diffusion in environments ranging from simple geometric shapes to realistic micro-geometries of biological tissue.
The MATLAB code contains recipes for the following exercises:
- Simulation of diffusion in 2D (illustrated in section 1. of the figure above)
- Checking the short-time limit of diffusion in a geometry composed of randomly packed impermeable cylinders in 2D (illustrated in section 2. of the figure above)
- Checking against known analytical formulas for diffusion within an impermeable non-absorbing cylinder in 2D (illustrated in section 3. of the figure above)
- Calculating a membrane’s permeability by starting diffusing particles from the center of the permeable cylinders in 2D (illustrated in section 4. of the figure above)
- Analytical solution of time-dependent diffusivity and kurtosis between parallel planes, inside cylinders, and inside spheres.
- Generation of randomly packed cylinders while tuning axonal water fraction, inner diameter distribution, and g-ratio. (Packing geometry is generated as in Donev et al. 2005; Axonal diameter histogram comes from Aboitiz et al. 1992.)
To learn more, see the related publication and references.
Questions about this resource may be directed to Hong Hsi Lee, MD, PhD at firstname.lastname@example.org.