Environment, Facilities, and Instrumentation

Environment


The NYU Langone Health System

Our Biomedical Technology Resource Center is part of NYU Langone Health, one of the largest health systems in New York City.

The major divisions of NYU Langone Health include Tish Hospital, NYU Langone Orthopedic Hospital, Hassenfeld Children's Hospital, NYU Hospital—Brooklyn, Rusk Rehabilitation, NYU School of Medicine, dozens of outpatient centers such as the Perlmutter Cancer Center and the NYU Langone Orthopedic Center, and an even greater number of outpatient practices spread throughout the metropolitan area.

In 2018, NYU Langone opened a new leading-edge inpatient pavilion and a state-of-the-art research tower, both located in midtown Manhattan.

NYU Langone's research environment is diverse and vibrant, with hundreds of research faculty and postdoctoral fellows, more than half a million square feet of research facilities, and hundreds of millions of dollars per year in federal research funding.


Department of Radiology

Our Center is closely integrated with NYU Langone's dynamic radiology department, which performs nearly two million imaging exams annually, employs more than two hundred attending radiologists, and operates approximately fifty MRI scanners throughout twenty-six state-of-the-art outpatient multimodality imaging clinics, with five more clinics expected to open by 2020.


CAI2R Headquarters

Our Center is headquartered in midtown Manhattan at 660 and 650 First Avenue. The Center staff are co-located with a large number of clinical radiologists (including those comprising the leadership of the radiology department), and are embedded within a broader radiology research team of approximately one hundred and thirty people, including more than thirty full-time research faculty and a diverse mix of students, fellows, administrators, and onsite industry scientists.

The close concentration of medical personnel and facilities with research staff and infrastructure underpins our unique collaborative model in which Center experts work with referring physicians, clinical radiologists, engineers, computer scientists, basic scientists, as well as embedded and external industry partners in matrixed teams that focus on rapid prototyping and frequent iteration.

Using our blended collaboration model and taking advantage of the scale and pace of the operations of the radiology department, we are able to dramatically shorten development and translation timelines for imaging technologies that address pressing clinical needs.

Our Center is headquartered four blocks north of NYU Langone's main medical, academic, and research campus; across the street from NYU Langone Orthopedic Center, two blocks east of NYU Langone Perlmutter Cancer Center, four blocks south-east of a newly opened outpatient imaging clinic on 41st Street, and a short walking distance from at least half-dozen other outpatient NYU Langone centers that dot east midtown Manhattan.

Facilities and Instrumentation


Human Imaging Systems

Our headquarters at 660 First Avenue is home to four state-of-the-art human MR and PET-MR imaging systems:

  • Siemens Prisma 3T MR scanner (scheduled to be outfitted with an Insightec MR-guided focused ultrasound system by mid 2019)
  • Siemens Skyra 3T MR scanner (scheduled to be replaced by a new Prisma system by the end of 2019)
  • Siemens 7T whole-body MR scanner (scheduled to be upgraded to a clinically-approved &T Terra system by the end of 2020)
  • Siemens Biograph mMR combined PET-MR scanner

Imaging systems at NYU Langone Orthopedic Center, across the street from our headquarters, include:

  • Siemens Skyra 3T MR scanner used for routine clinical musculoskeletal imaging
  • Siemens Aera 1.5T MR scanner used for routine clinical musculoskeletal imaging

In addition, our Center's staff have access to an intraoperative MR scanner at the Kimmel Pavilion, to various MR, PET, and CT scanners at Perlmutter Cancer Center, and to numerous other outpatient and inpatient scanners throughout the NYU Langone network.


Scanner Test Bay

An outpatient facility at 22nd Street, now housing a clinical MR scanner, will soon be converted to a test bay facility in which Siemens will install a prototype 1.5T scanner.

Low-level access to scanner hardware components will be provided in a dual-boot configuration to enable exploration of new hardware and software platforms for future scanners.


Radiofrequency (RF) Engineering Laboratory

Our Center's headquarters is home to state-of-the-art RF engineering laboratory equipped with precision circuit routers, dielectric probes, network analyzers, 3D printers, and other specialized equipment for design, prototyping, and construction, as well as for diagnostics and repairs of RF coils, anatomical housings, and biomorphic phantoms.

Our RF core staff have the expertise and instrumentation to build a range of MRI detectors, including workhorse clinical coils, specialized multinuclear coils, and novel high-impedance ultraflexible coils.


Phantom Laboratory

A separate phantom laboratory across the hall from the RF engineering core facility allows researchers to engineer substances that mimic tissue characteristics of interest.


Machine Shop

A machine shop, equipped with a lathe, a milling machine, a bench press drill, sawing machines, as well as other material-shaping hardware, is located in the basement of our headquarters. Combined with the RF laboratory, this resource enables us to build complete medical imaging device prototypes from scratch, as well as to significantly modify existing devices.


Cyclotron and Radiochemistry Laboratories

Our Center's headquarters also houses a cyclotron and two fully-equipped state-of-the-art radiochemistry facilities for the production of PET radiotracers.

The first-floor radiochemistry suite, adjacent to our PET-MR scanner, includes a Siemens RDS Eclipse 11 MeV cyclotron, and a production radiochemistry lab staffed by our industry partner PETNET. PETNET staff maintain the cyclotron and produce radiopharmaceuticals for NYU Langone's distributed clinical operations.

On the second floor, radiology department staff maintain a radiochemistry research laboratory with synthesizers and hot cells, a dedicated quality control laboratory with analytical high-performance liquid chromatography (HPLC) and gas chromatography systems, and a blood metabolite analysis laboratory with gamma counters, centrifuges, and additional HPLC analyzers. The facility can produce 11C, 18F, 13N, and 15O radioisotopes, create and validate radiotracers, and send doses to the human PET-MR system located directly one floor below, or to the micro-PET-CT system located in the preclinical imaging core, four blocks south.


Preclinical Imaging Laboratory

NYU Langone operates a preclinical imaging core, supported by our Center and by the NYU Langone Perlmutter Cancer Center.

The core, located four blocks south of our Center's headquarters, hosts two preclinical Brucer Biospec 7T micro-MRI systems and a Siemens Inveon micro-PET-CT scanner, along with instruments for bioluminescence and fluorescence optical imaging as well as for high-frequency ultrasound biomicroscopy. Facilities for microstructural validation are available nearby.


Microscopy Laboratory

NYU Langone operates a core microscopy laboratory located on the main medical, academic, and research campus, four blocks south of our Center's headquarters.

The laboratory is equipped with a range of light microscopes as well as a lineup of specialized tools for electron microscopy: microtomes, cryoultramicrotomes, coaters, dryers, freezers, and other instruments for preparation of samples and high-resolution imaging of specimens. These resources enable state-of-the-art validation of mesoscale structure of tissues.


Artificial Intelligence and Supercomputing

To enable leading-edge artificial intelligence studies, our department has installed a high-performance computing (HPC) cluster wholly dedicated to radiology research. The cluster, dubbed Skynet, is a 19-node HPC outfitted with the IBM Power9 systems and NVIDIA Volta GPUs. Skynet encompasses a total of 68 GPUs, 3,040 CPU cores, and 43,520 tensor cores.

Our staff can also access shared NYU Langone HPCs: Big Purple Compute Cluster with 54 Cray CS500 1U compute nodes; and Phoenix Compute Cluster with 75 nodes.


Biostatistics

The imaging biostatistics core resource is directed by James S. Babb, PhD, who is faculty member the Department of Radiology and a member of our Center's core staff. Dr. Babb has more than twenty years of experience in biostatistical evaluation of imaging techniques and is co-investigator on numerous NIH-funded imaging studies.

The core provides statistical support pertaining to study design (including randomization, stratification, and determination of sample size), data analysis, the presentation and summarization of results and the preparation of protocols and grant applications.


Tech4Health

Tech4Health is a new institute led by our Center's Principal Investigator Daniel Sodickson, MD, PhD, and by the Institute for Engineering in Biomedicine co-director Shy Shoham, PhD. Tech4Health aims at connecting engineering with biomedicine using an embedded collaboration approach, modeled after that of our Center.

Located twelve blocks south of our Center's headquarters, Tech4Health houses microscopy and photoacoustic equipment, and a maker space available to our Center's staff for research and development work involving sensors and other devices. Tech4Health also provides a connection to the NYU Tandon School of Engineering and its new Department of Biomedical Engineering.


Other Resources

Scientists from KU Leuven who are our partners in Technology Research and Development (TR&D) Project 3 maintain additional resources in Belgium.

Our global industry partners, including Siemens, Facebook AI Research, Insightec, Stratasys, and others, maintain diverse and extensive facilities around the world.

Sponsors

Latest Updates

11/12/2019 - 09:50
11/12/2019 - 09:49
11/12/2019 - 09:28

Philanthropic Support

We gratefully acknowledge generous support for radiology research at NYU Langone Health from:
 
• The Big George Foundation
• Raymond and Beverly Sackler
• Bernard and Irene Schwartz

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