Linda Moy

Linda Moy, MD
Professor of Radiology
Center for Biomedical Imaging, Radiology, NYU School of Medicine
4th Floor 660 First Avenue New York, NY 10016
Research Interest: 

The goal of my research to test, refine and validate novel dynamic breast MRI techniques to increase the diagnostic accuracy of breast MRI in the evaluation of breast cancer. Breast cancers are very heterogenous and mulitparametric breast MRI may allow for more personalized treatment of chemotherapy.  I have more than 15 years of clinical and research experience in using functional MR applications in breast MRI. I oversee the clinical 3T breast MRI Diagnostic and Interventional Program at the NYU Cancer Institute. Also, I collaborate with Dr. Brown and Madelin at the Center for Biomedical Imaging to develop our breast MRI and sodium MRI at 7T and to develop quantitative diffusion and perfusion MRI methods.  I have collaborated with Dr. Eric Sigmund and Dr. Sungheon Kim in exploring the roles of DCE-MRI and of intra-voxel incoherent motion (IVIM) imaging of tumor microenvironment in locally advanced breast cancer.  Another ongoing project is PET/MR of the breast.  My colleague, Amy Melsaether, MD, has been exploring the role of PET/MR in the evaluation of breast cancer and metastases.  Recently, we have collaborated with Kyunghyun Cho, PhD, at teh NYU Courant Institute to explore deep learning for screening mammography.  

Selected Publications: 

Moy L, Kopans DB, Slanetz PJ, Poller J, Moore RH.  The Specificity of Mammography and Ultrasound in the Evaluation of a Palpable Abnormality.  Radiology 2002 Oct;225(1):176-81.

Moy L, Ponzo F, Noz M, Maguire G, Deans A, Murphy-Walcott A, Kramer E.  A Prone MammoPET Acquisition Device Improves the Ability to Fuse MRI and PET Breast Scans. Clinical Nuclear Medicine  2007 Mar;32(3):194-8.

Moy L, Ponzo F, Noz M, Maguire G, Deans A, Murphy-Walcott A, Deans A, Kitazono MK, Travascio L, Kramer E.  Improving Specificity of Breast MRI Using Prone PET Imaging and Fused MRI and PET 3D Volume Data Sets. J Nucl Med. 2007 Apr;48(4):528-37.

Moy L, Elias K, Patel V, Lee J, Babb JS, Toth HK, Mercado CL.  Is breast MRI helpful in the evaluation of inconclusive mammographic findings?  American Journal of Roentgenology 2009 Oct;193(4):986-93.

Moy L, Noz ME, McGuire G, Melsaether A, Deans AE, Murphy A, Ponzo F.  Improving MR Specificity - Role of Fusion of Prone FDG-PET/CT and Magnetic Resonance Imaging of the Breasts in the Evaluation of Breast Cancer.  Breast Journal 2010 Jul-Aug;16(4):369-76.

Raykar VC, Yu S, Zhao LH, Valadez GH, Florin C, Bogoni L, Moy L.  Learning from the Crowds.  Journal of Machine Learning Research 2010 11(Apr):1297−1322.

Sigmund EE, Cho GY, Kim S, Finn M, Moccaldi M, Jensen J, Sodickson D, Goldberg J, Formenti S, Moy L.  Intra-voxel incoherent motion (IVIM) imaging of tumor microenvironment in Locally Advanced Breast Cancer.  Magnetic Resonance in Medicine 2011; 65:1437-1447.

Kim S, Decarlo L. Cho GY, Jensen H, Sodickson DK, Moy L, Formenti S, Schneider R, Goldberg JD, Sigmund EE.  Interstitial fluid pressure correlates with intra-voxel incoherent motion imaging metrics in mouse mammary carcinoma model. NMR in biomedicine 2012 May;25(5):787-94. doi: 10.1002/nbm.1793. Epub 2011 Nov 9.  PMID:22072561

Clendenen TV, Kim S, Moy L, Wan L, Rusinek H, Stanczcyk F, Pike MC, Zeleniuch-Jacquotte A. "Magnetic resonance imaging of hormone-induced breast changes in young premenopausal women”. , Magnetic Resonance Imaging 2013 Jan;31(1):1-9. doi: 10.1016/j.mri.2012.06.022. Epub 2012 Aug 13. PMID: 22898693

Heller SL, Moy L, Lavianlivi S, Moccaldi M, Kim S.  Magnetization Transfer Imaging and Dynamic Contrast Enhanced Imaging of Breast Cancer at 3T.  Journal of Magnetic Resonance Imaging 2013 Jan;37(1):138-45. doi: 10.1002/jmri.23786. Epub 2012 Oct 23. PMID: 23097239

Clendenen TV, Zeleniuch-Jacquotte A, Moy L, Pike MC, Rusinek H, Kim S. Comparison of 3-point Dixon imaging and fuzzy C-means clustering methods for breast density measurement.  J Magn Reson Imaging. 2013 Aug;38(2):474-81. doi: 10.1002/jmri.24002. Epub 2013 Jan 4. PMID:23292922

Amarosa AR, McKellop J, Klautau Leite AP, Moccaldi M, Clendenen T, Zeleniuch-Jacquotte A, Moy L, Kim S.  Evaluation of the kinetic properties of background parenchymal enhancement across phases of the menstrual cycle.  Radiology 2013 Aug;268(2):356-65. doi: 10.1148/radiol.13121101. Epub 2013 May 8. PMID:23657893

Brown R, Storey P, Geppert C, McGorty K, Klautau Leite AP, Babb J, Sodickson DK, Wiggins GC, Moy L.  Breast MRI at 7 Tesla with a bilateral coil and T1-weighted acquisition with robust fat suppression: image evaluation and comparison with 3 Tesla.  European Journal of Radiology, 2013  Nov;23(11):2969-78. doi: 10.1007/s00330-013-2972-1. Epub 2013 Jul 30. PMID:23896763

Heller SL, Elias K, Gupta A, Greenwood HI, Mercado CL, Moy L. Outcome of High-Risk Lesions at MRI-guided 9-gauge Vacuum Assisted Breast Biopsy.  American Journal of Roentgenology, 2014 Jan;202(1):237-45. doi: 10.2214/AJR.13.10600. PMID: 24370150  

Brown R, Storey P, McGorty K, Geppert C, Klautau Leite AP, Babb J, Sodickson DK, Wiggins GC, Moy L.  Breast MRI at 7 Tesla with a Bilateral Coil and Robust Fat Suppression.  Journal of Magnetic Resonance Imaging  2014 Mar;39(3):540-9. doi: 10.1002/jmri.24205. Epub 2013 Oct 7. PMID:24123517

Shaylor SD, Heller SL, Melsaether AN, Gupta D, Gupta A, Babb J, Moy L. Short Interval Follow-Up After A Benign Concordant MR-Guided Vacuum Assisted Breast Biopsy – Is it Worthwhile? Eur Radiol. 2014 Jun;24(6):1176-85. doi: 10.1007/s00330-014-3125-x. Epub 2014 Mar 14. PMID: 24623366

Melsaether AN, McDermott M; Gupta D, Pysarenko K, Shaylor SD, Moy L. Inter-reader Variability in Assessment of Background Parenchymal Enhancement on Breast MRI Improves with Dedicated Training.  American Journal of Roentgenology. 2014 Jul;203(1):209-15. doi: 10.2214/AJR.13.10952. PMID:


Cho GY, Moy L, Zhang JL, Lattanzi R, Baete S, Moccaldi, , Babb J, Kim S, Sodickson DK, Sigmund EE. Optimized b value selection for intravoxel incoherent motion (IVIM) analysis of diffusion-weighted imaging in breast cancer.  Magn Reson Med. 2014 Oct 9. doi: 10.1002/mrm.25484.  PMID:25302780 Margolies N, Bassiri-Tehrani B, Chhor C, Singer C, Hernandez O, Moy L.  Polyacrylamide Gel Breast Augmentation:  A Case-Based Review of the Literature. Clinical Imaging 2015 May-Jun;39(3):339-343. doi: 10.1016/j.clinimag.2014.12.008. Epub 2014 Dec 20. PMID: 25670236

Kim S, Feng L, Grimm R, Freed M, Block KT, Sodickson DK, Moy L, Otazo R. Assessment of iterative Golden-angle RAdial Sparse Parallel (iGRASP) MRI for breast dynamic contrast enhanced MRI. J Magn Reson Imaging. 2015 Jun 1. doi: 10.1002/jmri.24961.  PMID: 26032976  

Cho GY, Moy L, Kim S, Leite APK, Baete S, Babb JS, Sodickson DK, Sigmund EE.  Comparison of Contrast Enhancement and Diffusion-Weighted Magnetic Resonance Imaging in Healthy and Cancerous Breast Tissue, European Journal of Radiology. 2015 Jul 2. pii: S0720-048X(15)30030-9. doi: 10.1016/j.ejrad.2015.06.023. PMID: 26220915

Cho GY, Moy L, Kim SG, Babb J, Baete S, Sodickson DK, Sigmund EE. Evaluation of Breast Cancer using Intravoxel Incoherent Motion (IVIM) histogram analysis:  Comparison with malignant status, histological subtype, and molecular prognostic factors. European Radiology  2015 Nov 28.  PMID: 26615557

Lewin AR, Kim S,G Melsaether AN, McKellop J, Moccaldi M, Klautau Leite AP, Moy L. Differentiation of Benign from Malignant Non-Mass Enhancement in BRCA 1 Mutation Carriers Using Quantitative Kinetic Analysis. Acad Radiol. 2016 Mar;23(3):358-67. doi: 10.1016/j.acra.2015.11.011. Epub 2016 Jan 7. PMID: 26774741

Pujara AC, Raad RA, Ponzo F, Wassong C, Babb JS, Moy L, Melsaether AN.  Standardized Uptake Values from PET/MRI in Metastatic Breast Cancer: An Organ-based Comparison with PET/CT.  Breast J. 2016 May;22(3):264-73. doi: 10.1111/tbj.12569. Epub 2016 Feb 4. PMID: 26843433 

Heacock L, Melsaether AN, Heller SL, Gao Y, Pysarenko KM, Babb JS, Kim SG, Moy L. Evaluation of a Known Breast Cancer Using an Abbreviated Breast MRI Protocol: Correlation of Imaging Characteristics and Pathology with Lesion Detection.  European Journal of Radiology. 2016 Apr;85(4):815-23. doi: 10.1016/j.ejrad.2016.01.005. Epub 2016 Jan 19. PMID: 26971429

Melsaether AN, Rakheja R, Pysarenko K, Ponzo F, Jhaveri K, Sigmund EE, Kim S, Moy L. Comparison of whole body 18FDG-PET/MRI and whole body 18FDG-PET/CT in terms of lesion detection and radiation dose in breast cancer patients.  Radiology. 2016 Oct;281(1):193-202. doi: 10.1148/radiol.2016151155. PMID: 27023002  

Heller SL, Jaglan S, Babb JS, Melsaether A, Toth HB, Moy L.  Frequency of Discordant Lesions and False Negative Cancers at Stereotactic Vacuum Assisted Biopsy.  Academic Radiology 2016 Aug;23(8):994-9. doi: 10.1016/j.acra.2016.03.023. Epub 2016 May 5. PMID: 27161209

Margolis NE, Moy L, Pujara A, Amarosa A, Sigmund EE, Geppert C, Glielmi C, Freed M, Feng L, Otazo R, Melsather AN, Kim SG. Pharmacokinetic modeling in simultaneous dynamic contrast enhanced breast MRI and PET imaging. Clinical Nuclear Medicine.  2016 Aug;41(8):e355-61. doi: 10.1097/RLU.0000000000001254. PMID: 27187730

Freed M, Storey P, Lewin AA, Babb J, Moccaldi M, Moy L, Kim SG.  Evaluation of lipid composition in patients with benign tissue and cancer using multiple gradient echo MRI.  Radiology. 2016 Oct;281(1):43-53. doi: 10.1148/radiol.2016151959. PMID: 27266558

Gao Y, Bagadiya N, Jardon M, Heller SL, Melsaether AN, Toth HB, Moy L. Outcomes of Preoperative MR-imaging guided Needle Localization of Nonpalpable, Mammographically Occult Breast lesions. Am J Roentgenol. 2016 Sep;207(3):676-84. doi: 10.2214/AJR.15.15913. Epub 2016 Jun 8. PMID: 27275652

Teruel JR, Cho GY, Moccaldi M, Goa PE, Bathen TF, Kim SG, Moy L, Sigmund EE. Stimulated Echo Diffusion Tensor Imaging (STEAM-DTI) with Varying Diffusion Times as a Probe of Breast Tissue: preliminary experience. J Magn Reson Imaging. 2016 Jul 21. doi: 10.1002/jmri.25376. [Epub ahead of print] PMID: 27441890  

Melsaether A, Pujara AC, Elias K, Pysarenko K, Gudi A, Dodelzon K, Babb JS, Gao Y, Moy L. Background parenchymal enhancement over exam time in patients with and without breast cancer.  J Magn Reson Imaging. 2016 Jun 10. doi: 10.1002/jmri.25338. [Epub ahead of print] PMID: 27285396

Ostenson J,  Pujara AC, Mikheev A, Moy L, Kim SG, Melsaether AN, Jhaveri K, Adams S, Faul D, Glielmi C, Geppert C, Feiweier T, Jackson K, Cho GY, Boada FE, Sigmund EE.. Voxelwise Analysis of Simultaneously Acquired and Spatially Correlated 18-Fluorodeoxyglucose (FDG)-PET and Intravoxel Incoherent Motion Metrics in Locally Advanced Breast Cancer. Magnetic Resonance in Medicine Magn Reson Med. 2016 Oct 25. doi: 10.1002/mrm.26505. 

Lewin L, Heller S, Jaglan S, Elias K, Newburg A, Moy L.  Radiologic-Pathologic Discordance and Outcome After MRI-Guided Vacuum Assisted Biopsy. AJR Am J Roentgenol. 2016 Oct 27:W1-W6.

PMID: 27786559

Kim SG, Freed M, Klautau-Leite AP, Seuss C, Zhang J, Moy L.  Separation of benign and malignant breast lesions using dynamic contrast enhanced MRI in a biopsy cohort. J Magn Reson Imaging. 2016 Oct 20. doi: 10.1002/jmri.25501.PMID: 27766710

Newburg A, Chhor C, Lin LLY, Heller SL, Gillman J, Toth H, Moy L.  MRI-directed Ultrasound of Non-mass Enhancement: Outcomes and Frequency of Malignancy.  J Ultrasound Med. 2017 Jan 21. doi: 10.7863/ultra.16.03001.

Heacock L, Melsaether AN, Heller SL, Gao Y, Babb JS, Kim SG, Moy L. Comparison of Conventional DCE-MRI and a Novel Golden-Angle Radial Compressed-Sensing and Parallel Imaging Method for the Evaluation of Breast Lesion Conspicuity and Morphology.  J Magn Reson Imaging. 2016 Nov 17. doi: 10.1002/jmri.25530. [Epub ahead of print]  PMID: 27859874   



Philanthropic Support

We gratefully acknowledge generous support for radiology research at NYU Langone Medical Center from:
• The Big George Foundation
• Raymond and Beverly Sackler
• Bernard and Irene Schwartz

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