Jean Logan

Jean Logan, Ph.D
Senior Research Scientist
Function: 
Key Personnel
Affiliation: 
CAI²R
Fax: 
+1-212-263-7541
Address: 
4th Floor 660 First Avenue New York, NY 10016
Educational Details: 

1968 - Louisiana State University, Baton Rouge, LA-B.S.

1977 - Louisiana State University, Baton Rouge, LA-Ph.D.

1978-79 - Brookhaven National Laboratory, Upton, NY-Post-Doc

Selected Publications: 
  1. Logan J, Fowler JS, Ding Y-S, Franceschi D, Wang G-J, Volkow ND, Felder C, Alexoff D. (2002). A strategy for the formation of parametric images under conditions of low injected radioactivity applied to PET studies with the irreversible MAO A tracers [11C]clorgyline and deuterium substituted [11C]clorgyline. J. Cereb. Blood Flow Metab. 22:1367-76.
  2. Fowler JS, Logan J, Wang GJ, Franceschi D, Volkow ND, Telang F, Pappas N, Ferrieri R, Shea C, Garza V, Xu Y, King P, Schlyer D, Gatley SJ, Ding YS, Warner D, Netusil N, Carter P, Jayne M, Alexoff D, Zhu W, Vaska P. (2003). Monoamine oxidase A imaging in peripheral organs in healthy human subjects. Synapse 49:178-187.
  3. Logan J. (2003). A review of graphical methods for tracer studies and strategies to reduce bias. Nucl Med Biol. 30:833-844.
  4. Fowler JS, Logan J, Wang GJ, Volkow ND, Telang F, Ding YS, Shea C, Garza V, Xu Y, Li Z, Alexoff D, Vaska P, Ferrieri R, Schlyer D, Zhu W, Gatley S.J.(2004). Comparison of the binding of the irreversible monoamine oxidase tracers, [11C]clorgyline and [11C]l-deprenyl in brain and peripheral organs in humans. Nucl Med Biol. 31:313-319.
  5. Logan J, Ding Y, Lin K, Pareto D, Fowler J, Biegon A. (2005). Modeling and analysis of PET studies with norepinephrine transporter ligands: the search for a reference region. Nucl Med Biol 32:531-542.
  6. Logan, J, Wang G-J, Telang F, Fowler JS, Alexoff D, Zabroski J, Jayne M, Hubbard B, King P,Carter P, Shea C, Xu Y, Muench L, Schlyer D, Learned-Coughlin S, Cosson V,Volkow ND, Ding Y-S. (2007). Imaging the norepinephrine transporter in humans with (S,S) [11C]O-methylreboxetine and PET: problems and progress. Nucl Med Biol. 34(6):667-679.
  7. Logan J, Alexoff D, Kriplani A. (2007).Simplifications in analyzing positron emission tomography data: effects on outcome measures. Nucl Med Biol 34:743-756.
  8. Fowler JS, Volkow ND, Logan J, Alexoff D, Telang F, Wang GJ, Wong C, Ma Y, Kriplani A, Pradhan K, Schlyer D, Jayne M, Hubbard B, Carter P, Warner D, King P, Shea C, Xu Y, Muench L, Apelskog K. (2008). Fast uptake and long-lasting binding of methamphetamine in the human brain: comparison with cocaine. Neuroimage 43(4):756-763. PMCID: PMC2606665
  9. Volkow ND, Fowler JS, Logan J, Alexoff D, Zhu W, Telang F, Wang GJ, Jayne M, Hooker JM, Wong C, Hubbard B, Carter P, Warner D, King P, Shea C, Xu Y, Muench L, Apelskog-Torres K. (2009). Effects of modafinil on dopamine and dopamine transporters in the male human brain: clinical implications. JAMA 301(11):1148-1154. PMCID: PMC2696807
  10. Biegon A, Kim S, Alexoff D, Jayne M, Carter P, Hubbard B, King P, Logan J, Muench L, Pareto D, Schlyer D, Shea C, Telang F, Wang G, Xu Y, Fowler J. (2010a) Unique distribution of aromatase in the human brain: in vivo studies with PET and [N-methyl-11C]vorozole. Synapse 64:801-807. PMCID: PMC2941230
  11. Fowler J, Logan J, Azzaro A, Fielding R, Zhu W, Poshusta A, Burch D, Brand B, Free J, Asgharnejad M, Wang G, Telang F, Hubbard B, Jayne M, King P, Carter P, Carter S, Xu Y, Shea C, Muench L, Alexoff D, Shumay E, Schueller M, Warner D, Apelskog-Torres K. (2010) Reversible inhibitors of monoamine oxidase-A (RIMAs): robust, reversible inhibition of human brain MAO-A by CX157. Neuropsychopharmacology 35:623-631. PMCID: PMC2833271
  12. Logan J, Alexoff D, Fowler J. (2011) The use of alternative forms of graphical analysis to balance bias and precision in PET images. J Cereb Blood Flow Metab 31: 535-546. PMCID: PMC3049509
  13. Volkow ND, Tomasi D, Wang G-J, Telang F, Fowler JS, Logan J, Benveniste H, Kim R, Thanos PK, and Ferre S. (2012) Evidence that sleep deprivation downregulates dopamine D2R in ventral striatum in the human brain. J Neurosci 32: 6711-6717.
  14. Volkow ND, Wang G-J, Tomasi D, Kollins SH, Wigal TL, Newcorn JH, Telang FW, Fowler JS, Logan J, Wong CT, and Swanson JM. (2012) Methylphenidate-elicited dopamine increases in ventral striatum are associated with long-term symptom improvement in adults with attention deficit hyperactivity disorder. J Neurosci 32: 841-849. PMCID: PMC3350870
  15. Iliff JJ, Lee H, Yu M, Feng T, Logan J, Nedergaard M, Benveniste H. Brain-wide pathway for waste clearance captured by contrast-enhanced MRI. J Clin Invest 123: 1299-1309.

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Philanthropic Support

We gratefully acknowledge generous support for radiology research at NYU Langone Medical Center from:
 
• The Big George Foundation
• Raymond and Beverly Sackler
• Bernard and Irene Schwartz

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