James S. Babb

James S. Babb, PhD
Associate Professor, Biostatistician
Key Personnel
4th Floor 660 First Avenue New York, NY 10016
Educational Details: 

1980 - Cornell University, Ithaca, NY, B.S. - Neuro Biology

1984 - Cornell University, Ithaca, NY, M.S. - Animal Science

1986 - Cornell University, Ithaca, NY, M.S. - Biometry

1989 - Binghamton University, Binghamton, NY, M.A. - Mathematics

1996 - Binghamton University, Binghamton, NY, Ph.D - Mathematics

Research Interest: 

 Dr. Babb is an Associate Professor and a Biostatistician in the Department of Radiology at NYU School of Medicine. He has over 200 peer-reviewed research articles and has been a co-investigator on numerous NIH R01-funded basic science and clinical imaging grants over the last 20 years. He will be involved in the design of the statistical aspects of the project, in the supervision of the statistical analysis of the resulting data, and in statistical interpretation for TR&D #1, #2, and #3. 

Selected Publications: 

Xu J, McGorty KA, Lim RP, Bruno M, Babb JS, Srichai MB, Kim D, Sodickson DK. Single breathhold noncontrast thoracic MRA using highly accelerated parallel imaging with a 32-element coil array. J Magn Reson Imaging. 2012 Apr;35(4):963-8. doi: 10.1002/jmri.23535. Epub 2011 Dec 6. PMCID: PMC3305853. 

Moore SL, Kransdorf MJ, Schweitzer ME, Murphey MD, Babb JS. Can sarcoidosis and metastatic bone lesions be reliably differentiated on routine MRI? AJR Am J Roentgenol. 2012 Jun;198(6):1387-93. 

Chang G, Rajapakse CS, Babb JS, Honig SP, Recht MP, Regatte RR. In vivo estimation of bone stiffness at the distal femur and proximal tibia using ultra-high-field 7-Tesla magnetic resonance imaging and micro-finite element analysis. J Bone Miner Metab. 2012 Mar;30(2):243-51. Epub 2011 Nov 30. 

Wang L, Salibi N, Chang G, Vieira RL, Babb JS, Krasnokutsky S, Abramson S, Regatte RR. Assessment of subchondral bone marrow lipids in healthy controls and mild osteoarthritis patients at 3T. NMR Biomed. 2012 Apr;25(4):545-55. doi: 10.1002/nbm.1770. Epub 2011 Aug 18. PMCID:  PMC3292853. 

Madelin G, Babb JS, Xia D, Chang G, Jerschow A, Regatte RR. Reproducibility and repeatability of quantitative sodium magnetic resonance imaging in vivo in articular cartilage at 3 T and 7 T. Magn Reson Med. 2011 Dec 16. doi: 10.1002/mrm.23307. [Epub ahead of print] PMCID: PMC3340487.

Rosenkrantz AB, Mannelli L, Kong X, Niver BE, Berkman DS, Babb JS, Melamed J, Taneja SS. Prostate cancer: utility of fusion of T2-weighted and high b-value diffusion-weighted images for peripheral zone tumor detection and localization. J Magn Reson Imaging. 2011 Jul;34(1):95-100. doi: 10.1002/jmri.22598.

Gabbay V, Mao X, Klein RG, Ely BA, Babb JS, Panzer AM, Alonso CM, Shungu DC. Anterior cingulate cortex γ-aminobutyric acid in depressed adolescents: relationship to anhedonia. Arch Gen Psychiatry. 2012 Feb;69(2):139-49. doi: 10.1001/archgenpsychiatry.2011.131. Epub 2011 Oct 3.

Kirov II, Liu S, Fleysher R, Fleysher L, Babb JS, Herbert J, Gonen O. Brain metabolite proton T2 mapping at 3.0 T in relapsing-remitting multiple sclerosis. Radiology. 2010 Mar;254(3):858-66. PMCID: PMC2826702.

Gabbay V, Liebes L, Katz Y, Liu S, Mendoza S, Babb JS, Klein RG, Gonen O. The kynurenine pathway in adolescent depression: preliminary findings from a proton MR spectroscopy study. Prog Neuropsychopharmacol Biol Psychiatry. 2010 Feb 1;34(1):37-44. Epub 2009 Sep 21. PMCID: PMC2815014.

Falangola MF, Jensen JH, Babb JS, Hu C, Castellanos FX, Di Martino A, Ferris SH, Helpern JA. Age-related non-Gaussian diffusion patterns in the prefrontal brain. J Magn Reson Imaging. 2008
Dec;28(6):1345-50. PMCID: PMC2669671.

Lin K, Rapalino O, Law M, Babb JS, Siller KA, Pramanik BK. Accuracy of the Alberta Stroke Program Early CT Score during the first 3 hours of middle cerebral artery stroke: comparison of noncontrast CT, CT angiography source images, and CT perfusion. AJNR Am J Neuroradiol. 2008 May;29(5):931-6. Epub 2008 Feb 13.

Orbach DB, Wu C, Law M, Babb JS, Lee R, Padua A, Knopp EA. Comparing real-world advantages for the clinical neuroradiologist between a high field (3T), a phased array (1.5 T) vs. a single-channel 1.5-T MR system. J Magn Reson Imaging. 2006 Jul;24(1):16-24.

Wandler E, Kramer EL, Sherman O, Babb J, Scarola J, Rafii M. Diffuse FDG shoulder uptake on PET is associated with clinical findings of osteoarthritis. AJR Am J Roentgenol. 2005 Sep;185(3):797-803.

Manne S, Markowitz A, Winawer S, Meropol NJ, Haller D, Rakowski W, Babb J, Jandorf L. Correlates of colorectal cancer screening compliance and stage of adoption among siblings of individuals with early onset colorectal cancer. Health Psychol. 2002 Jan;21(1):3-15.

Movsas B, Li BS, Babb JS, Fowble BL, Nicolaou N, Gonen O. Quantifying radiation therapy-induced brain injury with whole-brain proton MR spectroscopy: initial observations. Radiology. 2001 Nov;221(2):327-31.

Research Projects: 

Prostate Cancer Detection Using High Spatial-Resolution MRI at 7.0 Tesla: Correlation with Histopathologic Findings at Radical Prostatectomy 
This study aims to perform high spatial-resolution prostate MRI at 7.0 Tesla in patients with prostate cancer awaiting radical prostatectomy. 

Local Radiation as an Adjuvant for Immunotherapy 
The major goals of this project are determine the mechanisms whereby ionizing radiation therapy (RT) promotes anti-tumor immunity by analyzing the critical steps of this process, i.e., tumor antigen presentation and T cell priming, and effector T cell trafficking and function within tumors. 

Quantitative MR Imaging and Proton Spectroscopy in MS 
The major goals of this project are: 1) to quantify the progressive neuronal damage incurred over the cause of this degenerative disease with proton magnetic resonance spectroscopy; 2) to serially assess the clinical deterioration of these patients; and 3) to correlate these clinical and radiological measures. 

Development and Evaluation of MRI Methods to Assess Diastolic Function 
The specific aims of the proposed research are to: 1) further develop technical methods for evaluation of diastole through tracking the motion of the atrioventricular junction, and 2) evaluate these methods in a sample of patients with heart failure and diastolic dysfunction and in matched control subjects. 

Evaluation and Prediction of Treatment Response in Liver Metastasis undergoing Chemotherapy with use of Dual Energy CT Iodine Quantification Technique 
The overall aim of this project is to validate the use of the quantitative measurement of tumor vascularity based on detecting intralesional iodine concentration obtained by contrast enhanced dual energy CT (DECT) to assess and predict treatment response in patients undergoing chemotherapy (with antiangiogenic agents) in liver metastasis from colon cancer. 

Dual Energy CT Evaluation of Airway Inflammation 
The purpose of the proposal is to provide a unique, quantitative, functional biomarker of airway inflammation by directly measuring bronchial wall enhancement following iodinated contrast administration using dual-energy computed tomography (DECT). 

Obesity, Insulin Resistance and Brain in Adolescence 
The purpose of the proposed study is to rigorously establish the nature of the cognitive impairments present among obese adolescents with IR and by means of a systematic and standardized neuropsychological and MRI-approach to further characterize the brain substrates for those abnormalities. 

Cartilage, Bone and Marrow Interactions in Knee OA 
The long-term objective is to develop a more effective means of identifying individuals at higher risk for knee OA progression via quantitative knee joint assessment of cartilage, trabecular bone and bone marrow. 

Osteoarthritis: Identification of Novel Imaging Biomarkers via 23Na/1H MRI at 7 T The goal of this K23
The goal of the research plan is to identify novel microstructural and biochemical imaging biomarkers of osteoarthritis (OA) via ultra high field (UHF) 7 Tesla (T) sodium and proton MRI techniques. 

Sodium MRI for Assessment of Early OA 
The overarching goal of this proposal is to develop, implement, and characterize novel fluid suppressed-3D- 23Na-UTE- techniques for in-vivo knee applications on an ultra high field system (7T). 

DCE MRI Study for Breast Cancer 
The research in this proposal will establish an innovative method of assessing chemotherapy that will significantly improve drug discovery and patient management in a variety of cancers including breast cancer. The proposed experiments in this application will lay important stepping stones toward utilizing this novel DCE-MRI method to improve patient management by allowing timely changes to ineffective treatment regimens. 



Latest Updates

07/15/2019 - 12:05
07/10/2019 - 10:06

Philanthropic Support

We gratefully acknowledge generous support for radiology research at NYU Langone Health from:
• The Big George Foundation
• Raymond and Beverly Sackler
• Bernard and Irene Schwartz

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