Einar M. Sigurdsson

Einar M. Sigurdsson, Ph.D.
Associate Professor; Departments of Neuroscience and Physiology
Function: 
Collaborator
Affiliation: 
CAI²R
Phone: 
212-263-3913
Fax: 
212-263-2160
Address: 
550 First Avenue New York, NY 10016
Educational Details: 

1990 - Pharmacy University of Iceland, Reykjavik, Iceland-M.Sc.Pharm.

1997 - Pharmacology Loyola University Chicago Medical Center Maywood, Illinois-Ph.D

1997-2000 - Departments of Pathology andNeurology, NYUSOM, NewYork, New York-Post-Doc

Selected Publications: 

Non-invasive, in vivo monitoring of neuronal transport impairment in a mouse model of tauopathy using MEMRI
Bertrand, Anne; Khan, Umer; Hoang, Dung M; Novikov, Dmitry S; Krishnamurthy, Pavan; Rajamohamed Sait, Hameetha B; Little, Benjamin W; Sigurdsson, Einar M; Wadghiri, Youssef Z
2013 Jan;64:693-702, Neuroimage
— id: 184812, year: 2013, vol: 64, page: 693, stat: Journal Article,

Antibody Uptake into Neurons Occurs Primarily via Clathrin-dependent Fcgamma Receptor Endocytosis and Is a Prerequisite for Acute Tau Protein Clearance
Congdon, Erin E; Gu, Jiaping; Sait, Hameetha B R; Sigurdsson, Einar M
2013 Dec;288(49):35452-35465, Journal of biological chemistry
— id: 712662, year: 2013, vol: 288, page: 35452, stat: Journal Article,

Two novel Tau antibodies targeting the 396/404 region are primarily taken up by neurons and reduce Tau protein pathology
Gu, Jiaping; Congdon, Erin E; Sigurdsson, Einar M
2013 Nov;288(46):33081-33095, Journal of biological chemistry
— id: 712162, year: 2013, vol: 288, page: 33081, stat: Journal Article,

Amyloid beta immunization worsens iron deposits in the choroid plexus and cerebral microbleeds
Joseph-Mathurin, Nelly; Dorieux, Olene; Trouche, Stephanie G; Boutajangout, Allal; Kraska, Audrey; Fontes, Pascaline; Verdier, Jean-Michel; Sigurdsson, Einar M; Mestre-Frances, Nadine; Dhenain, Marc
2013 Nov;34(11):2613-2622, Neurobiology of aging
— id: 540862, year: 2013, vol: 34, page: 2613, stat: Journal Article,

Tau pathology induces loss of GABAergic interneurons leading to altered synaptic plasticity and behavioral impairments
Levenga, Josien; Krishnamurthy, Pavan; Rajamohamedsait, Hameetha; Wong, Helen; Franke, Thomas F; Cain, Peter; Sigurdsson, Einar M; Hoeffer, Charles A
2013 ;1(1):34-34, Acta neuropathologica communications
— id: 712652, year: 2013, vol: 1, page: 34, stat: Journal Article,

Tau Immunotherapy and Imaging
Sigurdsson, Einar M
2013 Sep;:33081-33095, Neuro-degenerative diseases
— id: 712672, year: 2013, vol: , page: 33081, stat: Journal Article,

Cognitive and sensorimotor tasks for assessing functional impairments in mouse models of Alzheimer's disease and related disorders
Boutajangout, Allal; Li, Yong Sheng; Quartermain, David; Sigurdsson, Einar M
2012 ;849:529-540, Methods in molecular biology
— id: 165629, year: 2012, vol: 849, page: 529, stat: Journal Article,

Ab immunization in old mouse lemur primates induces cerebral microhemorrhages and accelerates age-associated iron deposits in the choroid plexus
Dorieux, O; Joseph-Mathurin, N; Trouche, S; Kraska, A; Santin, M; Boutajangout, A; Verdier, J -M; Sigurdsson, E M; Mestre-Frances, N; Dhenain, M
2012 2012;8(4):P626-P626, Alzheimer's and dementia
— id: 178076, year: 2012, vol: 8, page: P626, stat: Journal Article,

Loss of gabaergic interneuron in a mouse model for Tau pathology resulting in altered synaptic plasticity and behavior
Levenga, J; Krishnamurthy, P; Whelan, A; Rajamohamedsait, H; Wong, H; Sigurdsson, E; Hoeffer, C
2012 2012;8(4):P87-P87, Alzheimer's and dementia
— id: 178092, year: 2012, vol: 8, page: P87, stat: Journal Article,

Tau immunotherapy improves axonal transport as detected in vivo by manganese-enhanced magnetic resonance imaging
Little, B; Khan, U; Bertrand, A; Rajamohamedsait, H; Hill, L; Hoang, D M; Wadghiri, Y Z; Sigurdsson, E M
2012 2012;8(4):P166-P166, Alzheimer's and dementia
— id: 178089, year: 2012, vol: 8, page: P166, stat: Journal Article,

Tau immunotherapy improves axonal transport as detected in vivo by manganese-enhanced magnetic resonance imaging
Little, B; Khan, U; Bertrand, A; Rajamohamedsait, H; Hill, L; Hoang, D M; Wadghiri, Y Z; Sigurdsson, E M
2012 2012;8(4):P38-P38, Alzheimer's and dementia
— id: 178097, year: 2012, vol: 8, page: P38, stat: Journal Article,

Beneficial catalytic autoimmunity to beta-amyloid peptide
Nishiyama, Y; Planque, S; Hara, M; Watanabe, K; Xu, X; Taguchi, H; Sigurdsson, E M; O'Nuallain, B; Murray, I; Friedland, R P; Fukuchi, K -I; Massey, R; Paul, S
2012 2012;8(4):P706-P706, Alzheimer's and dementia
— id: 178073, year: 2012, vol: 8, page: P706, stat: Journal Article,

Histological Staining of Amyloid and Pre-amyloid Peptides and Proteins in Mouse Tissue
Rajamohamedsait, Hameetha B; Sigurdsson, Einar M
2012 ;849:411-424, Methods in molecular biology
— id: 165627, year: 2012, vol: 849, page: 411, stat: Journal Article,

Immunotherapy in tauopathies
Sigurdsson, E. M.
2012 OCT;22:S130-S130, European neuropsychopharmacology
— id: 370162, year: 2012, vol: 22, page: S130, stat: Journal Article,

In Vivo Magnetic Resonance Imaging of Amyloid-beta Plaques in Mice
Wadghiri, Youssef Zaim; Hoang, Dung Minh; Wisniewski, Thomas; Sigurdsson, Einar M
2012 ;849:435-451, Methods in molecular biology
— id: 165628, year: 2012, vol: 849, page: 435, stat: Journal Article,

Targeting hyperphosphorylated tau protein with a monoclonal antibodyat an advanced stage of tau pathology improves cognition in a mouse model
Boutajangout A.; Sait H.B.R.; Gonzalez V.; Sigurdsson E.
2011 ;7(4 SUPPL 1):S480-S481, Alzheimer's and dementia
— id: 136965, year: 2011, vol: 7, page: S480, stat: Journal Article,

Tau as a therapeutic target for Alzheimer's disease
Boutajangout, A; Sigurdsson, E M; Krishnamurthy, P K
2011 Sep 1;8(6):666-677, Current Alzheimer research
— id: 147678, year: 2011, vol: 8, page: 666, stat: Journal Article,

Passive immunization targeting pathological phospho-tau protein in a mouse model reduces functional decline and clears tau aggregates from the brain
Boutajangout, Allal; Ingadottir, Johanna; Davies, Peter; Sigurdsson, Einar M
2011 Aug;118(4):658-667, Journal of neurochemistry
— id: 135543, year: 2011, vol: 118, page: 658, stat: Journal Article,

Immunotherapy for tauopathies
Gu, Jiaping; Sigurdsson, Einar M
2011 Nov;45(3):690-695, Journal of molecular neuroscience
— id: 140523, year: 2011, vol: 45, page: 690, stat: Journal Article,

In vivo follow up of cerebral aging and side effects of anti-amyloid immunotherapies in the mouse lemur primate
Joseph-Mathurin N.; Dorieux O.; Kraska A.; Santin M.; Trouche S.; Boutajangout A.; Hantraye P.; Verdier J.-M.; Sigurdsson E.; Mestre-Frances N.; Dhenain M.
2011 ;7(4 SUPPL 1):S44-S44, Alzheimer's and dementia
— id: 136974, year: 2011, vol: 7, page: S44, stat: Journal Article,

In vivo follow-up of cerebral aging and side effects of anti-amyloid immunotherapies in the mouse lemur primate
Joseph-Mathurin N.; Dorieux O.; Kraska A.; Santin M.; Trouche S.; Boutajangout A.; Hantraye P.; Verdier J.-M.; Sigurdsson E.; Mestre-Frances N.; Dhenain M.
2011 ;7(4 SUPPL 1):S462-S463, Alzheimer's and dementia
— id: 136967, year: 2011, vol: 7, page: S462, stat: Journal Article,

Immunization with a pseudophosphorylated tau epitope clears tau pathology in a mouse model
Krishnamurthy P.; Gonzalez V.; Rajamohamedsait H.B.; Sigurdsson E.
2011 ;7(4 SUPPL 1):S481-S482, Alzheimer's and dementia
— id: 136964, year: 2011, vol: 7, page: S481, stat: Journal Article,

Therapeutic Applications of Antibodies - Antibodies in Non-Infectious Neurodegenerative Diseases
Krishnamurthy PK; Sigurdsson EM
2011 Sep;28(5):511-517, New biotechnology
— id: 130411, year: 2011, vol: 28, page: 511, stat: Journal Article,

Mechanistic Studies of Antibody-Mediated Clearance of Tau Aggregates Using an ex vivo Brain Slice Model
Krishnamurthy, Pavan K; Deng, Yan; Sigurdsson, Einar M
2011 ;2:59-59, Frontiers in psychiatry
— id: 139751, year: 2011, vol: 2, page: 59, stat: Journal Article,

Postsynaptic degeneration as revealed by PSD-95 reduction occurs after advanced Abeta and tau pathology in transgenic mouse models of Alzheimer's disease
Shao, Charles Y; Mirra, Suzanne S; Sait, Hameetha B R; Sacktor, Todd C; Sigurdsson, Einar M
2011 Sep;122(3):285-292, Acta neuropathologica
— id: 162988, year: 2011, vol: 122, page: 285, stat: Journal Article,

Immunotherapy targeting pathological tau prevents cognitive decline in a new tangle mouse model
Boutajangout, Allal; Quartermain, David; Sigurdsson, Einar M
2010 Dec 8;30(49):16559-16566, Journal of neuroscience
— id: 115432, year: 2010, vol: 30, page: 16559, stat: Journal Article,

Alzheimer's disease: challenges ahead
Sigurdsson, Einar M
2010 ;1:5-5, Frontiers in psychiatry
— id: 128803, year: 2010, vol: 1, page: 5, stat: Journal Article,

Murine models of Alzheimer's disease and their use in developing immunotherapies
Wisniewski, Thomas; Sigurdsson, Einar M
2010 Oct;1802(10):847-859, Biochimica & biophysica acta
— id: 112199, year: 2010, vol: 1802, page: 847, stat: Journal Article,

Diminished Amyloid-beta Burden in Tg2576 Mice Following a Prophylactic Oral Immunization with a Salmonella-Based Amyloid-beta Derivative Vaccine
Boutajangout, Allal; Goni, Fernando; Knudsen, Elin; Schreiber, Fernanda; Asuni, Ayodeji; Quartermain, David; Frangione, Blas; Chabalgoity, Alejandro; Wisniewski, Thomas; Sigurdsson, Einar M
2009 Jan 1;18(4):961-972, Journal of Alzheimer's Disease
— id: 107413, year: 2009, vol: 18, page: 961, stat: Journal Article,

Synthetic immunogenic but non-deposit-forming polypeptides and peptides homologous to amyloid beta, prion protein, amylin, alpha-synuclein, or polyglutamine repeats for induction of an immune response thereto
Frangione, Blas; Wisniewski, Thomas; Sigurdsson, Einar M
2009 ;27(7):957-964, Official gazette of the United States Patent & Trademark Office. Patents
— id: 97983, year: 2009, vol: 27, page: 957, stat: Journal Article,

Tau-focused immunotherapy for Alzheimer's disease and related tauopathies
Sigurdsson, Einar M
2009 Oct;6(5):446-450, Current Alzheimer research
— id: 105174, year: 2009, vol: 6, page: 446, stat: Journal Article,

Antibody response and plasma Abeta1-40 levels in young Microcebus murinus primates immunized with Abeta1-42 and its derivatives
Trouche, Stephanie G; Asuni, Ayodeji; Rouland, Sylvie; Wisniewski, Thomas; Frangione, Blas; Verdier, Jean-Michel; Sigurdsson, Einar M; Mestre-Frances, Nadine
2009 Feb 11;27(7):957-964, Vaccine
— id: 91348, year: 2009, vol: 27, page: 957, stat: Journal Article,

Synthetic immunogenic but non amyloidogenic peptides homologous to amyloid beta for induction of an immune response to amyloid beta and amyloid deposits
Frangione, Blas; Wisniewski, Thomas; Sigurdsson, Einar M
2008 ;27(7):957-964, Official gazette of the United States Patent & Trademark Office. Patents
— id: 97982, year: 2008, vol: 27, page: 957, stat: Journal Article,

High titers of mucosal and systemic anti-PrP antibodies abrogate oral prion infection in mucosal-vaccinated mice
Goni, F; Prelli, F; Schreiber, F; Scholtzova, H; Chung, E; Kascsak, R; Brown, D R; Sigurdsson, E M; Chabalgoity, J A; Wisniewski, T
2008 May 15;153(3):679-686, Neuroscience
— id: 99013, year: 2008, vol: 153, page: 679, stat: Journal Article,

Memantine leads to behavioral improvement and amyloid reduction in Alzheimer's-disease-model transgenic mice shown as by micromagnetic resonance imaging
Scholtzova, Henrieta; Wadghiri, Youssef Z; Douadi, Moustafa; Sigurdsson, Einar M; Li, Yong-Sheng; Quartermain, David; Banerjee, Pradeep; Wisniewski, Thomas
2008 Sep;86(12):2784-2791, Journal of neuroscience research
— id: 79463, year: 2008, vol: 86, page: 2784, stat: Journal Article,

Immunotherapy targeting pathological tau protein in Alzheimer's disease and related tauopathies
Sigurdsson, Einar M
2008 Nov;15(2):157-168, Journal of Alzheimer's Disease
— id: 90050, year: 2008, vol: 15, page: 157, stat: Journal Article,

A non-toxic ligand for voxel-based MRI analysis of plaques in AD transgenic mice
Sigurdsson, Einar M; Wadghiri, Youssef Z; Mosconi, Lisa; Blind, Jeffrey A; Knudsen, Elin; Asuni, Ayodeji; Scholtzova, Henrieta; Tsui, Wai H; Li, Yongsheng; Sadowski, Martin; Turnbull, Daniel H; de Leon, Mony J; Wisniewski, Thomas
2008 Jun;29(6):836-847, Neurobiology of aging
— id: 71031, year: 2008, vol: 29, page: 836, stat: Journal Article,

Immunotherapy targeting pathological tau conformers in a tangle mouse model reduces brain pathology with associated functional improvements
Asuni, Ayodeji A; Boutajangout, Allal; Quartermain, David; Sigurdsson, Einar M
2007 Aug 22;27(34):9115-9129, Journal of neuroscience
— id: 73919, year: 2007, vol: 27, page: 9115, stat: Journal Article,

Mucosal vaccination can prevent prion infection via an oral route
Wisniewski, T; Prelli, F; Scholtzova, H; Wu, H; Chung, E; Chabalgoity, JA; Sigurdsson, E; Sadowski, M; Goni, F
2007 ;68(12):A348-A348, Neurology
— id: 97602, year: 2007, vol: 68, page: A348, stat: Journal Article,

Therapeutic approaches for prion and Alzheimer's diseases
Wisniewski, Thomas; Sigurdsson, Einar M
2007 Aug;274(15):3784-3798, FEBS journal
— id: 73006, year: 2007, vol: 274, page: 3784, stat: Journal Article,

Vaccination of Alzheimer's model mice with Abeta derivative in alum adjuvant reduces Abeta burden without microhemorrhages
Asuni, Ayodeji A; Boutajangout, Allal; Scholtzova, Henrieta; Knudsen, Elin; Li, Yong Sheng; Quartermain, David; Frangione, Blas; Wisniewski, Thomas; Sigurdsson, Einar M
2006 Nov;24(9):2530-2542, European journal of neuroscience
— id: 69181, year: 2006, vol: 24, page: 2530, stat: Journal Article,

Plaque-associated overexpression of insulin-degrading enzyme in the cerebral cortex of aged transgenic tg2576 mice with Alzheimer pathology
Leal, Maria C; Dorfman, Veronica B; Gamba, Agata Fernandez; Frangione, Blas; Wisniewski, Thomas; Castano, Eduardo M; Sigurdsson, Einar M; Morelli, Laura
2006 Oct;65(10):976-987, Journal of neuropathology & experimental neurology
— id: 68945, year: 2006, vol: 65, page: 976, stat: Journal Article,

Assessing the effects of memantine in APP/PS1 transgenic mice by behavioural studies and ex vivo imaging of amyloid plaques using gadolinium labelled amyloid beta peptides and mu MRI
Scholtzova, H; Wadghiri, YZ; Sigurdsson, EM; Douadi, M; Li, Y; Quartermain, D; Banerjee, PK; Wisniewski, T
2006 SEP ;16(11):S483-S483, European neuropsychopharmacology
— id: 69190, year: 2006, vol: 16, page: S483, stat: Journal Article,

Immunotherapy for conformational diseases
Sigurdsson, Einar M
2006 ;12(20):2569-2585, Current pharmaceutical design
— id: 67007, year: 2006, vol: 12, page: 2569, stat: Journal Article,

Mucosal vaccination delays or prevents prion infection via an oral route
Goni, F; Knudsen, E; Schreiber, F; Scholtzova, H; Pankiewicz, J; Carp, R; Meeker, H C; Rubenstein, R; Brown, D R; Sy, M-S; Chabalgoity, J A; Sigurdsson, E M; Wisniewski, T
2005 ;133(2):413-421, Neuroscience
— id: 75837, year: 2005, vol: 133, page: 413, stat: Journal Article,

New directions towards safer and effective vaccines for Alzheimer's disease
Goni, Fernando; Sigurdsson, Einar M
2005 Feb;7(1):17-23, Current opinion in molecular therapeutics
— id: 55604, year: 2005, vol: 7, page: 17, stat: Journal Article,

Amyloid fibril formation by macrophage migration inhibitory factor
Lashuel, Hilal A; Aljabari, Bayan; Sigurdsson, Einar M; Metz, Christine N; Leng, Lin; Callaway, David J E; Bucala, Richard
2005 Dec 16;338(2):973-980, Biochemical & biophysical research communications
— id: 62130, year: 2005, vol: 338, page: 973, stat: Journal Article,

Amyloid proteins: methods and protocols
Sigurdsson, Einar M
Totowa, N.J. : Humana Press, 2005, 
— id: 858, year: 2005, vol: , page: , stat: ,

Histological staining of amyloid-beta in mouse brains
Sigurdsson, Einar M
2005 ;299:299-308, Methods in molecular biology
— id: 56370, year: 2005, vol: 299, page: 299, stat: Journal Article,

Promising developments in prion immunotherapy
Sigurdsson, Einar M; Wisniewski, Thomas
2005 Oct;4(5):607-610, Expert review of vaccines
— id: 62131, year: 2005, vol: 4, page: 607, stat: Journal Article,

Magnetic resonance imaging of amyloid plaques in transgenic mice
Wadghiri, Youssef Zaim; Sigurdsson, Einar M; Wisniewski, Thomas; Turnbull, Daniel H
2005 ;299:365-379, Methods in molecular biology
— id: 56371, year: 2005, vol: 299, page: 365, stat: Journal Article,

Antibody mediated modulation of A beta induced neurotoxicity in cell culture
Asuni, AA; Knudsen, E; Frangione, B; Wisniewski, T; Sigurdsson, EM
2004 JUL ;25(10):S581-S582, Neurobiology of aging
— id: 47745, year: 2004, vol: 25, page: S581, stat: Journal Article,

Synthetic immunogenic but non-amyloidogenic peptides homologous to amyloid beta for induction of an immune response to amyloid beta and amyloid deposits
Frangione, Blas; Wisniewski, Thomas; Sigurdsson, Einar M
2004 ;1280(5):S30-S31, Official gazette of the United States Patent & Trademark Office. Patents
— id: 97981, year: 2004, vol: 1280, page: S30, stat: Journal Article,

Monoclonal antibodies for the treatment of prion infection
Pankiewicz, J; Prelli, F; Scholtzova, H; Sadowski, M; Sigurdsson, EM; Goni, F; Kascsak, R; Kascsak, R; Carp, RI; Meeker, HC; Sy, MS; Wisniewski, T
2004 JUL ;25(10):S456-S456, Neurobiology of aging
— id: 47740, year: 2004, vol: 25, page: S456, stat: Journal Article,

Blocking the chaperoning effect of apolipoprotein E reduces beta-amyloid load in Alzheimer's disease transgenic mice
Sadowski, Marcin; Pankiewicz, Joanna; Scholtzova, Henrieta; Ripellino, James A.; Schmidt, Stephen D.; Mathews, Paul W.; Sigurdsson, Einar M.; Wisniewski, Thomas
2004 ;62(7, Suppl. 5):A522-A447, Neurology
— id: 97610, year: 2004, vol: 62, page: A522, stat: Journal Article,

A Synthetic Peptide Blocking the Apolipoprotein E/{beta}-Amyloid Binding Mitigates {beta}-Amyloid Toxicity and Fibril Formation in Vitro and Reduces {beta}-Amyloid Plaques in Transgenic Mice
Sadowski, Marcin; Pankiewicz, Joanna; Scholtzova, Henrieta; Ripellino, James A; Li, Yongsheng; Schmidt, Stephen D; Mathews, Paul M; Fryer, John D; Holtzman, David M; Sigurdsson, Einar M; Wisniewski, Thomas
2004 Sep;165(3):937-948, American journal of pathology
— id: 44511, year: 2004, vol: 165, page: 937, stat: Journal Article,

In vivo magnetic resonance of amyloid plaques in Alzheimer's disease model mice
Sigurdsson, E; Wadghiri, YZ; Sadowski, M; Elliott, JI; Li, YS; Scholtzova, H; Tang, CY; Aguinaldo, G; Duff, K; Turnbull, DH; Wisniewski, T
The living brain and Alzheimer's disease Berlin : Springer, 2004, 
— id: 4970, year: 2004, vol: , page: 47, stat: Chapter,

An attenuated immune response is sufficient to enhance cognition in an Alzheimer's disease mouse model immunized with amyloid-beta derivatives
Sigurdsson, Einar M; Knudsen, Elin; Asuni, Ayodeji; Fitzer-Attas, Cheryl; Sage, Daniel; Quartermain, David; Goni, Fernando; Frangione, Blas; Wisniewski, Thomas
2004 Jul 14;24(28):6277-6282, Journal of neuroscience
— id: 44513, year: 2004, vol: 24, page: 6277, stat: Journal Article,

Modest immune response elicited by A beta derivatives in TG2576 mice improves cognition
Sigurdsson, EM; Knudsen, E; Asuni, A; Sage, D; Goni, F; Quartermam, D; Frangione, B; Wisniewski, T
2004 JUL ;25(10):S576-S576, Neurobiology of aging
— id: 47744, year: 2004, vol: 25, page: S576, stat: Journal Article,

In vivo magnetic resonance imaging of amyloid plaques in mice with a non-toxic A beta derivative
Sigurdsson, EM; Wadghiri, YZ; Blind, JA; Knudsen, E; Asuni, A; Sadowski, M; Turnbull, DH; Wisniewski, T
2004 JUL ;25(10):S57-S57, Neurobiology of aging
— id: 47715, year: 2004, vol: 25, page: S57, stat: Journal Article,

Detection of Alzheimer's amyloid lesions in transgenic mice by magnetic resonance imaging
Sigurdsson, EM; Wadghiri, YZ; Li, YS; Elliott, JI; Tang, CY; Aguilnaldo, G; Duff, K; Pappolla, M; Watanabe, M; Scholtzova, H; Turnbull, DH; Wisniewski, T
2004 FEB ;25(2):251-251, Neurobiology of aging
— id: 42486, year: 2004, vol: 25, page: 251, stat: Journal Article,

Imaging and therapeutic approaches for beta-sheet structures in prion and Alzheimer's diseases
Wisniewski, T; Pankiewicz, J; Scholtzova, H; Fernando, G; Chabalgoity, JA; Ji, Y; Wadghiri, YZ; Gan, WB; Tang, CY; Turnbull, DH; Mathis, CA; Kascsak, R; Klunk, WE; Carp, RI; Frangione, B; Sigurdsson, EM; Sadowski, M
2004 ;25(2):S30-S31, Neurobiology of aging
— id: 97595, year: 2004, vol: 25, page: S30, stat: Journal Article,

Reduction of beta-amyloid load in Alzheimer's disease transgenic mice by competitive blocking of beta-amyloid binding to apolipoprotein E
Wisniewski, T; Pankiewicz, J; Scholtzova, H; Schmidt, SD; Mathews, PM; Sigurdsson, EM; Sadowski, M
2004 JUL ;25(10):S583-S583, Neurobiology of aging
— id: 47746, year: 2004, vol: 25, page: S583, stat: Journal Article,

In vivo imaging of amyloid plaques in AD and prion disease model mice
Wisniewski, T; Sigurdsson, EM; Wadghiri, YZ; Carp, R; Tang, CY; Turnbull, DH; Mathis, C; Klunk, WE; Gan, WB; Sadowski, M
2004 APR ;25(12):S29-S29, Neurobiology of aging
— id: 42446, year: 2004, vol: 25, page: S29, stat: Journal Article,

Immunization with amyloid - beta derivatives improves cognition while provoking a weak antibody response
Knudsen, E. L.; Wisniewski, T.; Quartermain, D.; Sage, D.; Scholtzova, H.; Frangione, B.; Sigurdsson, E. M.
2003 ;2003(5):Abstract No. 133.10-S31, Society for Neuroscience Abstract Viewer & Itinerary Planner
— id: 97630, year: 2003, vol: 2003, page: Abstract No. 133.10, stat: Journal Article,

Inhibition of apolipoprotein E binding to amyloid - beta decreases fibril formation and deposition in vitro and in vivo
Sadowski, M.; Ji, Y.; Scholtzova, H.; Pankiewicz, J.; Sigurdsson, E. M.; Wisniewski, T.
2003 ;2003(5 Supplement 1):Abstract No. 666.6-118, Society for Neuroscience Abstract Viewer & Itinerary Planner
— id: 97615, year: 2003, vol: 2003, page: Abstract No. 666.6, stat: Journal Article,

Blocking apolipoprotein E/beta-amyloid interaction as a therapeutic approach for Alzheimer's disease
Sadowski, Marcin; Ji, Yong; Scholtzova, Henrieta; Sigurdsson, Einar M.; Wisniewski, Thomas
2003 ;60(5 Supplement 1):A68-118, Neurology
— id: 97613, year: 2003, vol: 60, page: A68, stat: Journal Article,

Copper modulates prion infectivity
Sigurdsson, E. M.; Brown, D.; Alim, M. A.; Scholtzova, H.; Carp, R.; Meeker, H. C.; Prelli, F.; Frangione, B.; Wisniewski, T.
2003 ;2003(47):Abstract No. 631.2-46202, Society for Neuroscience Abstract Viewer & Itinerary Planner
— id: 97631, year: 2003, vol: 2003, page: Abstract No. 631.2, stat: Journal Article,

Copper chelation delays the onset of prion disease
Sigurdsson, Einar M; Brown, David R; Alim, Muhammad A; Scholtzova, Henrieta; Carp, Richard; Meeker, Harry C; Prelli, Frances; Frangione, Blas; Wisniewski, Thomas
2003 Nov 21;278(47):46199-46202, Journal of biological chemistry
— id: 48185, year: 2003, vol: 278, page: 46199, stat: Journal Article,

Anti-prion antibodies for prophylaxis following prion exposure in mice
Sigurdsson, Einar M; Sy, Man-Sun; Li, Ruliang; Scholtzova, Henrieta; Kascsak, Richard J; Kascsak, Regina; Carp, Richard; Meeker, Harry C; Frangione, Blas; Wisniewski, Thomas
2003 Jan 23;336(3):185-187, Neuroscience letters
— id: 34146, year: 2003, vol: 336, page: 185, stat: Journal Article,

Detection of Alzheimer's amyloid in transgenic mice using magnetic resonance microimaging
Wadghiri, Youssef Zaim; Sigurdsson, Einar M; Sadowski, Marcin; Elliott, James I; Li, Yongsheng; Scholtzova, Henrieta; Tang, Cheuk Ying; Aguinaldo, Gilbert; Pappolla, Miguel; Duff, Karen; Wisniewski, Thomas; Turnbull, Daniel H
2003 Aug;50(2):293-302, Magnetic resonance in medicine
— id: 38795, year: 2003, vol: 50, page: 293, stat: Journal Article,

in vivo magnetic resonance imaging of amyloid plaques in AD model mice
Wisniewski, T.; Sigurdsson, E. M.; Wadghiri, Y. Z.; Sadowski, M.; Scholtzova, H.; Tang, C. Y.; Aguilnaldo, G.; Duff, K.; Turnbull, D. H.
2003 ;2003(2):Abstract No. 203.7-302, Society for Neuroscience Abstract Viewer & Itinerary Planner
— id: 97618, year: 2003, vol: 2003, page: Abstract No. 203.7, stat: Journal Article,

Immunization approaches for the treatment of prion disease
Wisniewski, Thomas; Sy, Man-Sun; Sadowski, Marcin; Kascsak, Richard J.; Kascsak, Regina; Carp, Richard; Goni, Fernando; Sigurdsson, Einar
2003 ;60(5 Supplement 1):A250-302, Neurology
— id: 97619, year: 2003, vol: 60, page: A250, stat: Journal Article,

A safer vaccine for Alzheimer's disease?
Frangione, B; Wisniewski, T; Sigurdsson, EM
2002 Jul-Aug;23(1):1579-, Neurobiology of aging
— id: 32430, year: 2002, vol: 23, page: 1579, stat: Journal Article,

Molecular targeting of Alzheimer's amyloid plaques for contrast-enhanced magnetic resonance imaging
Poduslo, JF; Wengenack, T; Curran, GV; Macura, S; Borowski, B; Jack, C; Wisniewski, T; Sigurdsson, E
2002 ;23(1):1550-329, Neurobiology of aging
— id: 97596, year: 2002, vol: 23, page: 1550, stat: Journal Article,

Molecular targeting of Alzheimer's amyloid plaques for contrast-enhanced magnetic resonance imaging
Poduslo, JF; Wengenack, TM; Curran, GL; Wisniewski, T; Sigurdsson, EM; Macura, SI; Borowski, BJ; Jack, CR
2002 Jun;81(7):61-61, Journal of neurochemistry
— id: 32368, year: 2002, vol: 81, page: 61, stat: Journal Article,

Molecular targeting of Alzheimer's amyloid plaques for contrast-enhanced magnetic resonance imaging
Poduslo, Joseph F; Wengenack, Thomas M; Curran, Geoffry L; Wisniewski, Thomas; Sigurdsson, Einar M; Macura, Slobodon I; Borowski, Bret J; Jack, Clifford R Jr
2002 Nov;11(2):315-329, Neurobiology of disease
— id: 62132, year: 2002, vol: 11, page: 315, stat: Journal Article,

SAFETY OF POTENTIAL VACCINES FOR ALZHEIMER'S DISEASE
Scholtzova, H.; Wisniewski, T.; Ahlawat, S.; Watanabe, M.; Quartermain, D.; Frangione, B.; Sigurdsson, E. M.
2002 ;2002(6):Abstract No. 227.1-46202, Society for Neuroscience Abstract Viewer & Itinerary Planner
— id: 97632, year: 2002, vol: 2002, page: Abstract No. 227.1, stat: Journal Article,

VACCINATION DELAYS THE ONSET OF PRION DISEASE IN MICE
Sigurdsson, E. M.; Brown, D. R.; Daniels, M.; Kascsak, R. J.; Kascsak, R.; Carp, R.; Meeker, H. C.; Watanabe, M.; Scholtzova, H.; Frangione, B.; Wisniewski, T.
2002 ;2002(6):Abstract No. 692.15-413, Society for Neuroscience Abstract Viewer & Itinerary Planner
— id: 97633, year: 2002, vol: 2002, page: Abstract No. 692.15, stat: Journal Article,

Immunization delays the onset of prion disease in mice
Sigurdsson, Einar M; Brown, David R; Daniels, Maki; Kascsak, Richard J; Kascsak, Regina; Carp, Richard; Meeker, Harry C; Frangione, Blas; Wisniewski, Thomas
2002 Jul;161(1):13-17, American journal of pathology
— id: 32479, year: 2002, vol: 161, page: 13, stat: Journal Article,

A safer vaccine for Alzheimer's disease?
Sigurdsson, Einar M; Wisniewski, Thomas; Frangione, Blas
2002 Nov-Dec;23(6):1001-1008, Neurobiology of aging
— id: 32918, year: 2002, vol: 23, page: 1001, stat: Journal Article,

Infectivity of amyloid diseases
Sigurdsson, Einar M; Wisniewski, Thomas; Frangione, Blas
2002 Sep;8(9):411-413, Trends in molecular medicine
— id: 32920, year: 2002, vol: 8, page: 411, stat: Journal Article,

Immunization for Alzheimer's disease
Sigurdsson, EM; Frangione, B; Wisniewski, T
2002 Jun;56(2):135-142, Drug development research
— id: 32447, year: 2002, vol: 56, page: 135, stat: Journal Article,

In vivo detection of Alzheimer's amyloid by magnetic resonance imaging
Sigurdsson, EM; Wadghiri, YZ; Li, Q; Scholtzova, H; Tang, CY; Aguilnaldo, JG; Duff, K; Pappolla, M; Elliott, JI; Watanabe, M; Turnbull, DH; Wisniewski, T
2002 Jul-Aug;23(1):1307-, Neurobiology of aging
— id: 32425, year: 2002, vol: 23, page: 1307, stat: Journal Article,

Prion related diseases
Wisniewski T; Sigurdsson E
2002;:- [Web site], 2002-, Emedicine
— id: 150918, year: 2002, vol: , page: , stat: Web Site,

PASSIVE IMMUNIZATION WITH ANTI - PrP ANTIBODIES PROLONGS PRION INCUBATION PERIOD
Wisniewski, T.; Sy, M. S.; Li, R.; Scholtzova, H.; Kascsak, R. J.; Kascsak, R.; Carp, R.; Meeker, H. C.; Frangione, B.; Sigurdsson, E. M.
2002 ;2002(6):Abstract No. 692.16-413, Society for Neuroscience Abstract Viewer & Itinerary Planner
— id: 97634, year: 2002, vol: 2002, page: Abstract No. 692.16, stat: Journal Article,

Therapeutics in Alzheimer's and prion diseases
Wisniewski, T; Brown, D R; Sigurdsson, E M
2002 Aug;30(4):574-578, Transactions (Biochemical Society (Great Britain))
— id: 32922, year: 2002, vol: 30, page: 574, stat: Journal Article,

Vaccination delays the onset of prion disease in mice
Wisniewski, T; Scholtzova, H; Watanabe, M; Ji, Y; Frangione, B; Sigurdsson, EM; Brown, DR; Daniels, M; Kasesak, RJ; Kascsak, R
2002 Jul-Aug;23(1):496-, Neurobiology of aging
— id: 32412, year: 2002, vol: 23, page: 496, stat: Journal Article,

Immunization treatment approaches in Alzheimer's and prion diseases
Wisniewski, Thomas; Sigurdsson, Einar M
2002 Sep;2(5):400-404, Current neurology & neuroscience reports
— id: 32923, year: 2002, vol: 2, page: 400, stat: Journal Article,

Distinct properties of wild-type and the amyloidogenic human cystatin C variant of hereditary cerebral hemorrhage with amyloidosis, Icelandic type
Calero M; Pawlik M; Soto C; Castano EM; Sigurdsson EM; Kumar A; Gallo G; Frangione B; Levy E
2001 Apr;77(2):628-637, Journal of neurochemistry
— id: 20351, year: 2001, vol: 77, page: 628, stat: Journal Article,

Amyloid beta40/42 clearance across the blood-brain barrier following intra-ventricular injections in wild-type, apoE knock-out and human apoE3 or E4 expressing transgenic mice
Ji Y; Permanne B; Sigurdsson EM; Holtzman DM; Wisniewski T
2001 Feb;3(1):23-30, Journal of Alzheimer's Disease
— id: 32921, year: 2001, vol: 3, page: 23, stat: Journal Article,

Immunization with a nontoxic/nonfibrillar amyloid-beta homologous peptide reduces Alzheimer's disease-associated pathology in transgenic mice
Sigurdsson EM; Scholtzova H; Mehta PD; Frangione B; Wisniewski T
2001 Aug;159(2):439-447, American journal of pathology
— id: 23485, year: 2001, vol: 159, page: 439, stat: Journal Article,

Immunization with a soluble and non-toxic amyloid-beta derivative substantially impedes Alzheimer's disease associated pathology in transgenic mice
Sigurdsson, E. M.; Schwaninger, J.; Scholtzova, H.; Mehta, P. D.; Ji, Y.; Ahlawat, S.; Sparks, C. M.; Quartermain, D.; Frangione, B.; Wisniewski, T.
2001 ;27(2):1807-447, Abstracts (Society for Neuroscience)
— id: 97635, year: 2001, vol: 27, page: 1807, stat: Journal Article,

Conformation as a therapeutic target in the prionoses and other neurodegenerative conditions
Wisniewski T; Sigurdsson EM; Aucouturier P; Frangione B
Molecular pathology of the prions Totowa NJ: Humana Press, 2001, 
— id: 2638, year: 2001, vol: , page: ?, stat: Chapter,

Conformation as therapeutic target in the prionoses and other neurodegenerative conditions
Wisniewski, T; Sigurdsson, E M; Aucouturier, P; Frangione, B
2001 ;59:223-236, Methods in molecular medicine
— id: 156282, year: 2001, vol: 59, page: 223, stat: Journal Article,

Amyloid-beta injection in rat amygdala alters tau protein but not mRNA expression
Chambers CB; Sigurdsson EM; Hejna MJ; Lorens SA; Lee JM; Muma NA
2000 Mar;162(1):158-170, Experimental neurology
— id: 23486, year: 2000, vol: 162, page: 158, stat: Journal Article,

In vivo reversal of amyloid-beta lesions in rat brain
Sigurdsson EM; Permanne B; Soto C; Wisniewski T; Frangione B
2000 Jan;59(1):11-17, Journal of neuropathology & experimental neurology
— id: 8565, year: 2000, vol: 59, page: 11, stat: Journal Article,

In vivo disassembly of cerebral amyloid-beta (Abeta) deposits in rat brain
Sigurdsson, E. M.; Permanne, B.; Soto, C.; Wisniewski, T.; Frangione, B.
1999 ;25(1-2):1805-78, Abstracts (Society for Neuroscience)
— id: 97639, year: 1999, vol: 25, page: 1805, stat: Journal Article,

beta-sheet breaker peptides prevent the formation of amyloid-beta deposits
Soto C; Sigurdsson EM; Morelli L; Kumar RA; Saborio GP; Castano EM; Frangione B 
Alzheimer's disease and related disorders Chichester, NY: Wiley, 1999, 
— id: 2639, year: 1999, vol: , page: ?, stat: Chapter,

beta-sheet breaker peptides as potential therapy for Alzheimer's disease
Sigurdsson, EM; Morelli, L; Kumar, RA; Castano, EM; Frangione, B; Soto, C
1998 NOV ;1(1):S35-S36, Alzheimer's reports
— id: 98326, year: 1998, vol: 1, page: S35, stat: Journal Article,

Beta-sheet breaker peptides inhibit fibrillogenesis in a rat brain model of amyloidosis: implications for Alzheimer's therapy [see comments]
Soto C; Sigurdsson EM; Morelli L; Kumar RA; Castano EM; Frangione B
1998 Jul;4(7):822-826, Nature medicine
— id: 7803, year: 1998, vol: 4, page: 822, stat: Journal Article,

Bilateral injections of amyloid-beta 25-35 into the amygdala of young Fischer rats: behavioral, neurochemical, and time dependent histopathological effects
Sigurdsson EM; Lee JM; Dong XW; Hejna MJ; Lorens SA
1997 Nov-Dec;18(6):591-608, Neurobiology of aging
— id: 23487, year: 1997, vol: 18, page: 591, stat: Journal Article,

Laterality in the histological effects of injections of amyloid-beta 25-35 into the amygdala of young Fischer rats
Sigurdsson EM; Lee JM; Dong XW; Hejna MJ; Lorens SA
1997 Jun;56(6):714-725, Journal of neuropathology & experimental neurology
— id: 23489, year: 1997, vol: 56, page: 714, stat: Journal Article,

Local and distant histopathological effects of unilateral amyloid-beta 25-35 injections into the amygdala of young F344 rats
Sigurdsson EM; Lorens SA; Hejna MJ; Dong XW; Lee JM
1996 Nov-Dec;17(6):893-901, Neurobiology of aging
— id: 23488, year: 1996, vol: 17, page: 893, stat: Journal Article,

Visual processing in Alzheimer's Disease
Celesia GG; Villa AEP; Brigell M; Lee JM; Sigurdsson E
Alzheimer's and Parkinson's diseases New York: Plenum Press, 1995, 
— id: 2637, year: 1995, vol: , page: 1, stat: Chapter,

Degenerative disease: Alzheimer's - beta-amyloid
Sigurdsson EM
1995 ;4:17-22, Meeting reports. CNS
— id: 23496, year: 1995, vol: 4, page: 17, stat: Journal Article,

beta-Amyloid 25-35 and/or quinolinic acid injections into the basal forebrain of young male Fischer-344 rats: behavioral, neurochemical and histological effects
Sigurdsson EM; Hejna MJ; Lee JM; Lorens SA
1995 Dec 14;72(1-2):141-156, Behavioural brain research
— id: 23490, year: 1995, vol: 72, page: 141, stat: Journal Article,

Sponsors

Philanthropic Support

We gratefully acknowledge generous support for radiology research at NYU Langone Health from:
 
• The Big George Foundation
• Raymond and Beverly Sackler
• Bernard and Irene Schwartz

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