Technology Research & Development Project #3

Advancing MR and PET Through Synergistic Simultaneous Acquisition and Joint Reconstruction

Although the complementary contrast provided by MR and PET scans certainly calls for multimodality combination, the advent of combined MR-PET scanners provides opportunities much greater than the simple superposition of MR datasets and PET datasets. For TR&D #3, we will use the novel continuous acquisition approaches developed in TR&D #1, along with additional innovations in image acquisition and reconstruction, to improve the fundamental capabilities of PET, and in general to make MR-PET greater than the sum of its single-modality components. We will explore 1) motion correction based on simultaneous MR and PET acquisition, for improved spatial and temporal resolution; 2) combined image reconstruction taking advantage of joint sparsity, etc; 3) joint tracer kinetic modeling; and 4) development of PET tracers for use in PET and MR-PET studies. In summary, TR&D #3 is not merely a “PET” core, or even an “MR-PET” core. It will result in imaging techniques that go beyond MR alone, PET alone, or even traditional “multimodality” approaches to create a truly integrated imaging paradigm with heretofore inaccessible performance. Dr. Fernando Boada, our BTRC Co-Director and innovator in basic and translational MR science, and Dr. Yu-Shin Ding, who is well known for her leadership in radiochemistry, will be joined by Dr. Johan Nuyts in leading a research team which has been expanded substantially since our original submission, and which includes dedicated expertise in MR and PET image acquisition and reconstruction, tracer kinetic modeling, radiochemistry, etc.

Sponsors

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Philanthropic Support

We gratefully acknowledge generous support for radiology research at NYU Langone Medical Center from:
 
• The Big George Foundation
• Raymond and Beverly Sackler
• Bernard and Irene Schwartz

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